Advanced Diffusion MRI in Neurological Diseases

The Multiple Sclerosis Model

Simona Schiavi, Ph.D.1; Matilde Inglese, M.D., Ph.D.1,2
1 Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI), University of Genoa, Italy
2 IRCCS Ospedale Policlinico San Martino, Genoa, Italy


Diffusion MRI can play an essential role in better understanding the pathophysiology of MS and in monitoring the disease course and, possibly, response to treatments. Here we provide examples of the research applications and the potential clinical impact of this technique that has not been fully exploited to date. The use of multishell sequences coupled with advanced microstructural models and quantitative tractography might really help to investigate multiple sclerosis pathophysiology and monitor structural connectivity changes.

Advanced Diffusion MRI in Neurological Diseases: The Multiple Sclerosis Model

Matilde Inglese, MD, PhD, et al. (University of Genoa, Italy)

Matilde Inglese, M.D., Ph.D. (University of Genoa, Italy / Icahn School of Medicine at Mount Sinai, New York, NY, USA)

Professor Matilde Inglese, M.D., Ph.D.

Professor Matilde Inglese, M.D., Ph.D.
University of Genoa, DINOGMI
Largo Paolo Daneo 3
16134, Genoa