High-res PD-SPACE for segmentation with Chondral Quant

Chondral Quant is a syngo.via application for automatic, quantitative and structured evaluation of knee cartilage. It takes the complexity out of knee cartilage evaluation and increases efficiency and reproducibility of examinations. Osteoarthritis progression and treatment success can easily be monitored with Chondral Quant. By detecting osteoarthritis, therapy options can be adjusted, supporting patients to maintain excellent quality of life.

Are you looking for a clinically validated 3D PD TSE SPACE FS that can be used as 3D morphological scan for Chondral Quant?

Charles P. Ho, M.D., Ph.D., and Lauren Watkins, Ph.D. (Steadman Philippon Research Institute, Vail, CO, USA) share their protocol for 3T MAGNETOM Verio (software version syngo MR E11).

Here is a brief description of the sequences:

  • Sagittal PD-weighted SPACE sequence with fat suppression: 
    This isotropic sequence (or as close as possible) can be used to visualize bone, cartilage, fluid, and synovium interfaces for accurate segmentation and quantification of the volume of each joint structure. Reformatting in sagittal, coronal, and axial planes allows for additional accuracy in delineating surfaces and interfaces. Acute injuries with high signal intensity findings representing edema, inflammation, or hemorrhage within the soft tissue and bone may also be detected.
  • Coronal T1-weighted sequence: 
    A non-fat suppressed T1-weighted sequence provides good SNR and fat contrast for detecting bone processes such as edema and masses or neoplasms. This sequence may also be used to detect chronic soft tissue and fat scarring. However, there is little soft tissue contrast other than for fat.
  • Sagittal PD-weighted sequence: 
    A non-fat suppressed PD-weighted sequence provides soft tissue and fluid contrast with good SNR.
  • Axial T2-weighted sequence
    A non-fat suppressed T2-weighted sequence is used to assess areas with true fluid signal. A fat-saturated sequence could mistake prominent soft tissue degeneration such as meniscus or chondral degeneration for a tear or defect, respectively.
  • Sagittal T2 mapping sequence: 
    A multi-echo spin echo sequence is used for quantitative T2 relaxation time mapping to evaluate cartilage biochemical composition and integrity. T2 relaxation time in cartilage is sensitive to water and collagen content and organization. A sagittal sequence is used to evaluate and map cartilage in the medial, lateral, and patellofemoral compartments. Given the low resolution and 2D nature of the sequence, cartilage is delineated first on the SPACE sequence and transferred to the T2 relaxation time map to more accurately define regions of cartilage within the T2 relaxation time map and avoid adjacent bone and fluid-containing voxels.

Jan Fritz


Lauren Watkins, Ph.D.
Principal Scientist for Imaging Research
Steadman Philippon Research Institute
108 S Frontage Rd W, Suite 300
Vail, Colorado 81657

Charles Ho


Charles P. Ho, Ph.D., M.D.
Steadman Philippon Research Institute
181 West Meadow Drive, Suite 1000
Vail, CO 81657
Phone: +1 (970) 479-9797