MAGNETOM World

Magnetic Resonance Fingerprinting

A new dimension in quantitative MRI

Siemens - MRI - Magnetic Resonance Fingerprinting


MRF is a potentially disruptive new approach to quantitative data acquisition, while reducing complexity in imaging.

MRF is designed to provide quantitative multiparametric maps with a high level of robustness and reproducibility. This type of signal acquisition could enable a new level of comparability and consistency in MRI.
Through multiparametric maps acquired simultaneously, MRF is designed to enable tissue characterization with quantitative parameters to help detect and analyze early tissue changes.
Case Western Reserve University (CWRU) exclusively partners with Siemens Healthcare in order to further refine this highly promising method of quantitative tissue analysis. 

 
 
 

Motivation and technique

Siemens - MRI - Fingerprinting - In essence
Courtesy of Prof. Mark Griswold, Case Western Reserve University, Cleveland, OH, USA.

The MRF technique does not acquire traditional clinical images, but instead is designed to gather tissue information based on the signal evolution for voxels. Acquisition parameters are varied in a pseudorandom fashion, and the signal evolutions are recorded and collected in a database or ‘dictionary’. After the acquisition, a pattern recognition algorithm is used to find the dictionary entry that best represents the acquired signal evolution of each voxel. The signal evolutions equate in many ways to ‘fingerprints’ of tissue properties, which, like the identification of human fingerprints in forensics, can only be analyzed by comparing them with a file containing all known fingerprints. The dictionary is equivalent to the database where all the known fingerprints are stored, together with all the information relative to each person. In the forensic case, each fingerprint points to the feature identification of the associated person such as name, height, weight, eye color, date of birth, etc. In the case of MRF, each fingerprint in the dictionary points to the MR related identification features of the associated tissue (such as T1, T2, relative spin density, B0, diffusion, etc.).
 

"A potentially new, disruptive approach to clinical diagnostic imaging with the potential to quantitatively detect and analyze complex changes that can represent physical alterations of a substance or early indications of disease."1


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MRF has the potential to be less sensitive to motion in comparison to conventional MR acquisition techniques.

Imaging examples

MR Fingerprinting is currently in use for research at University Hospital Essen (Germany), and the Medical University of Vienna (Austria). Studies are being conducted in brain tumors and other neurological disorders, liver, heart and in the prostate.


Siemens - MRI - MAGNETOM World - MR Fingerprinting - Case Study: MRF Imaging of the Brain - Siegfried Trattnig

Case Study: MRF Imaging of the Brain

Siegfried Trattnig et al., Medical University Vienna, Austria

Siemens - MRI - MR Fingerprinting - Going towards a database of quantitative values
Images courtesy of Prof. Siegfried Trattnig, Medical University of Vienna, Austria

MRF has the potential to provide quantitative parameters, to help differentiate tumors in the brain.

Ongoing MRF study on multiple sclerosis patients to collect MRF data
Images courtesy of Prof. Siegfried Trattnig, Medical University of Vienna, Austria

Asymptomatic patient with Multiple Sclerosis.

Siemens - MRI - Fingerprinting - Quantitative Liver Imaging
Images courtesy of Vikas Gulani, University Hospitals Case Medical Center, Case Western Reserve University, Cleveland, OH, USA.

MRF is designed to acquire all information in a single scan and to provide:

  • multiple quantitative maps
  • perfect coregistration of different maps
  • acquisition in a single breath-hold scan

This cannot be achieved by conventional methods that require multiple, separate scans.

Siemens - MRI - MR Fingerprinting - Designed for quantitative prostate imaging
Images courtesy of Vikas Gulani, University Hospitals Case Medical Center, Case Western Reserve University, Cleveland, OH, USA

Patient with prostate cancer in the left peripheral zone with reduced T1 and T2 values in MRF maps.

MRF Clinical Case Study - Prostate
Images courtesy of University Hospital Essen, Germany

MRF case study of biopsy confirmed low grade prostate cancer

(Gleason score 3+3).

Siemens - MRI - Fingerprinting - Qalitative Cardiac Imaging
Images courtesy of Nicole Seiberlich, Case Western Reserve University, Cleveland, OH, USA.

Cardiac MRF compared to conventional mapping techniques: MRF has the potential to provide similar values to current quantitative methods.

Articles and talks

Nicole Seiberlich (University of Michigan, Ann Arbor, MI, USA)

Clinical Benefits of MR Fingerprinting

Meiyun Wang; Henan Provincial People's Hospital, China

Preview of the article Novelties in MR Fingerprinting

Novelties in MR Fingerprinting

Gregor Körzdörfer, Siemens Healthineers, Erlangen, Germany

Application of MRF in Epilepsy

Application of MRF in Epilepsy

Dan Ma, et al., Case Western Reserve University, Cleveland, OH, USA

MR Fingerprinting in the Brain – Precise Quantitative MRI

Gregor Koerzdoerfer, Ph.D., Siemens Healthineers Lunch Symposium ESMRMB 2019, Rotterdam, NL

Exploring New Frontiers in MRI

Sascha Daeuber, Ph.D., Siemens Healthineers Lunch Symposium ESMRMB 2019, Rotterdam, NL

MR Fingerprinting. A New Path for Clinical Quantitative MR

Dan Ma (Case Western Reserve University, Cleveland, OH, USA), ISMRM Lunch Symposium, Montréal, Canada, 2019

Tissue Segmentation and Partial Volume Estimation with Magnetic Resonance Fingerprinting

Tissue Segmentation and Partial Volume Estimation with Magnetic Resonance Fingerprinting

Dan Ma, et al., Case Western Reserve University, Cleveland, OH, USA

Siemens - MRI - MAGNETOM World - Hot Topics - MR-Fingerprinting - Magnetic Resonance Field Fingerprinting - Nittka

Magnetic Resonance Field Fingerprinting (MRF)

Mathias Nittka, Ph.D., et al., Siemens Healthineers, Erlangen, Germany
 

Overview of MR Fingerprinting

Overview of MR Fingerprinting

Vikas Gulani et al., Dept. of Radiology, Case Western Reserve University, University Hospitals Case Medical Center, Cleveland, OH, USA
 

7T MR and MR Fingerprinting – Will They Shape the Future of MR?

Siegfried Trattnig, Dept. of Biomedical Imaging and Image-guided Therapy, MR Centre of Excelence, Medical University of Vienna, Austria

(MRF starts at 14:45)

New Application Opportunities Using MR Fingerprinting

Mark Griswold, Case Western Reserve University (Cleveland, USA),
9th MAGNETOM World Summit in Oxfordshire, UK

MR Fingerprint Imaging at 7T*; the New Way of Imaging!

Mark Griswold, Case Western Reserve University (Cleveland, USA),
4th Ultra-High Field User Meeting, Vienna, Austria